DuoLife Clinical Formula ProBactilardii®

DuoLife Clinical Formula ProBactilardii® is a complex dietary supplement, consisting of 2 complementary capsules. The Synbiotic capsule contains a prebiotic (in the form of acacia fibre) and the proprietary BACTILARDII® probiotic formula, based on 4 bacterial strains and 1 yeast strain, whose viability is guaranteed at the end of the product’s shelf life. The Postbiotic capsule – contains a postbiotic in a formula based on butyric acid. DuoLife Clinical Formula ProBactilardii® features not only an innovative composition, but also a patented formula and direct packaging, ensuring maximum protection of microbial strains contained inside the capsule.

Description

DuoLife Clinical Formula ProBactilardii® is a complex dietary supplement, consisting of 2 complementary capsules. The Synbiotic capsule contains a prebiotic (in the form of acacia fibre) and the proprietary BACTILARDII® probiotic formula, based on 4 bacterial strains and 1 yeast strain, whose viability is guaranteed at the end of the product’s shelf life. The Postbiotic capsule – contains a postbiotic in a formula based on butyric acid. DuoLife Clinical Formula ProBactilardii® features not only an innovative composition, but also a patented formula and direct packaging, ensuring maximum protection of microbial strains contained inside the capsule.
What lives within us?

The intestinal microflora of a healthy human includes approximately 100 trillion (!) beneficial microorganisms (bacteria, fungi and even viruses), by number exceeding 10 times the total number of cells in the human body.
Up to 500-1000 beneficial species of microorganisms can live in the human intestines, most in the large intestine. The composition of the microbiota depends on many factors, however bacteria of the genus Bacteroides, Bifidobacterium and Lactobacillus are almost always dominant.
In addition to genetic determinants, the composition of gut microbiota can be affected mainly by age, diet, geographical region, sanitation and medicines used.
The composition and abundance of the microbiome can be disrupted by, among other things:
  • excessive stress,
  • change in lifestyle,
  • fatigue,
  • diseases,
  • antibiotic use,
  • sudden change in diet, e.g. due to a change in location, travel to tropical or exotic countries with diverse diet.
The health-promoting effects of microorganisms living in the digestive tract are documented by thousands of clinical studies and scientific reports. They confirm that a well-functioning microbiome benefits:
DuoLife Clinical Formula ProBactilardii® is recommended for:

1. people who want to support the optimal digestive function on a daily basis, including but not limited to:
people with disorders of the natural gut microbiota, including constipation or diarrhoea;
people with digestive problems related to excessive stress;
people with lactose intolerance;
people who want to support natural digestive processes;
people seeking to maintain proper colon health;
people who want to support optimal biosynthesis of B vitamins and vitamin K in the large intestine;
2. people who want to support the functions of their immune system, including those with reduced immunity due to excessive stress;
3. people who want to support the optimal functions of their central nervous system, including:
optimal mood;
emotional balance.
4. people during and after antibiotic treatment (antibacterial and/or antifungal).
5. people planning trips, especially to exotic and tropical countries, with a different diet, to be used before and during the trip.
DuoLife Clinical Formula ProBactilardii® supports:

proper function of the gastrointestinal tract in healthy people;
proper function of the gastrointestinal tract during antibiotic therapy;
function of the gastrointestinal tract during diarrhoea and bacterial, viral and fungal infections;
function of the gastrointestinal tract in people living under excessive stress;
optimal function of the immune system;
proper function of the gut microbiota;
optimal condition of the large intestine;
proper digestive processes;
optimal biosynthesis of B vitamins and vitamin K in the large intestine;
function of the central nervous system – especially optimal mood and emotional balance;
proper lactose metabolism;
antioxidative processes;
proper blood cholesterol level;
removing toxins from the body;
restoration of gut microbiota after bacterial, viral and fungal infections of the gastrointestinal tract.
What makes DuoLife Clinical Formula ProBactilardii® different?
Innovative composition – a combination of prebiotic, probiotic and postbiotic in one product
PROBIOTICS are products containing selected live strains of microorganisms that have a beneficial effect on the human body by improving the balance of the gut microbiota. The strains contained in DuoLife Clinical Formula ProBactilardii® have broad, clinically documented health-promoting properties.
PREBIOTICS are products that are selectively used by beneficial microorganisms of the microflora (mainly intestinal, but not only) in humans, bringing health benefits to the human body. The acacia fibre used in DuoLife Clinical Formula ProBactilardii® belongs to the soluble fibre fraction. It stimulates the development of natural intestinal microflora, promotes optimal functions of the digestive tract, supports intestinal peristalsis, regulating bowel movements and preventing flatulence and chronic constipation.
POSTBIOTICS are defined as the combination of all bioactive ingredients produced by bacteria, e.g. during fermentation, which are beneficial when introduced into the human body. The butyric acid used in DuoLife Clinical Formula ProBactilardii® has been shown to have beneficial effects in supporting digestive and immune function. It is naturally biosynthesized in the large intestine and its supplementation can support the effects of butyric acid synthesized in the intestines. Butyric acid promotes the optimal condition of the intestines, supports the intestinal barrier functions, intestinal peristalsis, nourishes intestinal epithelial cells, can support the body’s fight against local inflammation in the intestine.
Proprietary Bactilardii® formula
4 strains of live, freeze-dried, selected and branded bacterial strains (Bifidobacterium bifidum Rosell® R0071, Bifidobacterium longum Rosell® R0175, Lactobacillus helveticus Rosell® R0052 and Lactobacillus rhamnosus Rosell® R0011) in DuoLife proprietary proportions plus 1 billion yeast strains (Saccharomyces boulardii CNCM I-1079).
Concentrated formula
Concentrated formula – the total amount of microorganisms is 9 billion CFU = 9×109 CFU (CFU = colony-forming unit) of LIVE freeze-dried bacteria and yeast cultures GUARANTEED in the formula AT THE END OF THE PRODUCT’S SHELF LIFE. The concentrated dose provides convenient use, usually 1 time per day both capsules combined.
Viability
Laboratory-confirmed viability of bacterial and yeast cultures is guaranteed in the formula at the end of the product’s shelf life.
Stability and viability of micro-organisms
The stability and survivability of the microorganisms has been tested and laboratory confirmed in a reputable laboratory in the United States.
Clinical tests
The performance of individual microbial strains has been documented by NUMEROUS clinical trials, including at least 30 clinical trials for the specific Lallemand strains used in the product (R0011, R0052, R0175 and R0071). All clinical studies have also demonstrated a high safety profile of the tested bacterial strains in humans.
Results of preclinical trials of strains R0175 and R0052 (7 trials in total), which demonstrated barrier effect of the strains and their adhesion to intestinal epithelium determining probiotic health-promoting effects
Figure A: Adhesion of Lactobacillus rhamnosus Rosell® R0011 bacilli (A) and Lactobacillus helveticus Rosell® R0052 bacilli (B) to the intestinal epithelial cells determining their probiotic effect. Bacteria are indicated by white arrows. Picture from an electron microscope, based on i.
The results of clinical trials using the Bifidobacterium bifidum Rosell® R0071 strain
Resistance during passage through the digestive tract
Resistance during passage through the gastrointestinal tract has been confirmed in an experimental study performed for the R0052 and R0011 strains using an in vitro model (IViDiS, in vitro Digestive System). It confirms the good stability of the strains in gastric and duodenal environment ii.
Conclusions: The survival of strains R0052 and R0011 is optimal up to 90 minutes of passage through the stomach and another 90 minutes through the duodenum, which allows concluding about the stability of the strains throughout the passage through the upper part of the gastrointestinal tract under physiological conditions.
Clinical trials in healthy volunteers taking the dietary supplement with the R0011 strain showed good survival of bacteria throughout the human gastrointestinal tract.
Conclusions: The number of R0011 strain bacilli in the faeces of the subjects before consuming the supplement (3 weeks, exclusion) and during consumption (12 days, consumption) and during the one-week wash-out period.
Conclusions: The number of R0011 strain bacilli in the faeces of the subjects before consuming the supplement (3 weeks, exclusion) and during consumption (12 days, consumption) and during the one-week wash-out period.
Synergistic health-promoting effect on the gut-brain axis
Clinical trials confirm that the combination of the R0175 and R0052 bacterial strains contained in DuoLife Clinical Formula ProBactilardii® has a positive effect on the gut-brain axis, helping to improve both gastrointestinal and central nervous system (CNS) function. This combination has a beneficial effect on psychological functions in healthy people, helping to maintain an optimal mood and promoting protection against the adverse effects of stress on the function of the gastrointestinal tract and the central nervous system. It also helps alleviate the intestinal ailments caused by excessive emotions.
Clinical trial results supporting synergistic health-promoting effects on the gut-brain axis, strain combinations: Bifidobacterium longum Rosell® R0175 and Lactobacillus helveticus Rosell® R0052. The amounts and proportions of the R0175 and R0052 bacterial strain colonies used in clinical trials correspond to the amounts contained in the DuoLife Clinical Formula ProBactilardii® preparation.
Figure 1. The synergistic effect of R0052 and R0175 strains has been documented in clinical trials conducted in 2011 (A) and 2008 (B). Figure A: Improvement of psychological functions (global mood score; HSCL-90 Global Severity Index) compared to placebo, combined with a decrease in urinary stress biomarker (cortisol) with 30 days of use for both strains (3×109 CFU in total) in 55 healthy volunteers. Figure B: Average improvement in gut function in 75 healthy volunteers exposed to occasional stress during 21 days of using a mixture of R0052 and R0175 strains. Based on iv-vi. Placebo = reference group, not receiving probiotics.
Optimal protection of strains
Proprietary innovative formulation protects strains from adverse conditions and from stomach acid and bile with proprietary BIO-SUPPORT™ technology. The stability of the strains within the gastrointestinal tract has been proven in preclinical in vitro tests and in clinical studies. The microgranules are further protected by delayed-release HPMC capsules, all encapsulated in patented, drug-certified ACTIV-VIALTM direct packaging with Activ-Polymer™ lining that minimizes the ingress of moisture, light and oxygen to the capsules in the container, protecting bacterial and yeast strains and other ingredients during product storage
BIO-SUPPORT™ technology action scheme – ensuring protection of all
Lallemand strains
Patented, innovative, drug-certified ACTIV-VIAL™ direct packaging
Convenience
No refrigeration required, recommended storage at room temperature 20-25°C.
Natural ingredients
Including 4 bacterial strains and 1 yeast strain in the form of LIVE freeze-dried microorganisms. The natural substance that protects the strains against the harmful effects of atmospheric oxygen is vitamin C of natural origin – L-ascorbic acid (described on the label as an antioxidant, pursuant to the EU Regulation (EC) 1831/2003).
Less is more
It contains no artificial fillers and is GMO and gluten free.
Vege
Suitable for vegans and vegetarians

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